The Mekong Delta is too large and varied to sell as one generic destination. A short visit near Ho Chi Minh City, a night in Cần Thơ and a two-night stay in Châu Đốc offer very different trips.
For most first-time travellers, the real decision is not whether to “do the Mekong” but which part of it is worth the available time.
Bến Tre is strongest for coconut country and smaller waterways. Cần Thơ is a comfortable river city and the base for Cái Răng. Châu Đốc and An Giang bring pilgrimage, border trade and a very different western landscape.

